ZMT Zurich MedTech AG Zeughausstrasse 43 CH-8004 Zurich, Switzerland Dear Valued Customer, We are greatly pleased to provide you with Sim4Life Version 4.4. This DVD or the download site contains an installer for Sim4Life, our multiscale simulation platform for computational BioMed and Life Sciences applications in complex anatomies, for 64 bit Windows architectures. The file also contains optional installations for tutorial examples as well as relevant manual and tutorial documentation. In addition, an installer for the iSeg segmentation toolset is provided. To install Sim4Life on your computer, please run the installer which was downloaded or which is included on the DVD. You will then be automatically guided through the installation. When the installation is complete, there will be a Sim4Life icon in your Start Menu as well as a Sim4Life folder containing useful shortcuts. You can optionally install the documentation, tutorial examples, and configure and install the Message Passing Interface (MPI). MPI is available for parallel computation in a number of the provided solvers. When you start Sim4Life for the first time, you will be asked to specify a license file or a license server. Licenses are issued by ZMT Zurich MedTech AG. If you have purchased a dongle protection, you will need to install the dongle driver "FLEXidInstaller.exe" stored in the Flexlm directory. Please consult the chapter "Licensing" in the Manual within the "Documentation" directory for more information. If necessary, please do also update the path pointing to the iSeg executable from within the Sim4Life Global Preferences. The Sim4Life documentation is included in the "Documentation" directory and provides more information about the program and the tutorial projects. We greatly welcome any suggestions from you. Please do not hesitate to contact us by e-mail via s4l-support@zmt.swiss. We will strive to adapt Sim4Life to your needs. Kind regards, The Sim4Life Team s4l-support@zmt.swiss