Physics Models: P-ACOUSTICS
Acoustics Solvers
The two full wave Acoustics Solvers (P-ACOUSTICS) encompass 1) a Graphics Processing Unit (GPU) and OpenMP accelerated non-linear FDTD method with an extended Westervelt-Lighthill equation applied to adaptive rectilinear meshes with inhomogeneous PML boundary conditions and 2) a fast near-field method combined with the hybrid angular spectrum approach (FNM-CHASM) to simulate complex wave propagation inside inhomogeneous tissue distributions and to rapidly calculate pressure distributions for applications such as focused ultrasound treatments. This is state-of-art in computational acoustics.
Precise ablation of a liver tumor located behind the ribs considering respiratory movements.
The novel ultrasound solvers account for pressure wave propagation, density variations and jumps, non-linearity, and diffusivity losses that occur in human tissue.
The FNM-CHASM solver offers near real-time simulations of acoustic propagation in inhomogeneous setups.
The P-ACOUSTICS solvers have been extensively validated and the associated uncertainties have been quantified using analytical solutions, benchmarks, and robotic 3D-scan hydrophone measurements in complex setups. Comprehensive documentation is available for Sim4Life.
- FUS-Based Bbb Disruption for Increased Delivery of Neuro-Active Agents
- FUS-Based Thrombolysis
- FUS-Based Neural Stimulation
- MRgFUS Neurosurgery Applications: Tumor Ablation, Neuropathic Pain Treatment, Movement Disorders
- Sound Exposure (e.g., in MRI)
Key Features
- Linear & non-linear 3D full-wave solvers based on the Westervelt-Lighthill equation (expanded with density variation terms to account for the presence of bones & strongly reflecting material)
- Novel hybrid solver combining the fast near-field method (FNM) & the hybrid angular spectrum method (hASM) allowing for near real-time simulations of setups involving ultrasonic transducers with a principal propagation direction
- Multi-core and GPU acceleration (fastest ultrasonic solver on the market)
- Applicable to both audible acoustics and therapeutic ultrasound simulations
- Coupled with the thermal solver to calculate temperature increases induced by deposited acoustic energy
- Tailored to the simulation of entirely heterogeneous simulation domains
- Capable of simulating entire therapeutic FUS setups involving large anatomical models in minutes
- Tailored to the simulation of large ultrasonic arrays comprising hundreds to thousands of piezoelectric elements
- Enables simulations with arbitrarily shaped transducers & arrays
- Equipped with inhomogeneous PML modules, allowing for domain truncation through an inhomogeneous anatomy, thus restricting the domain size without the need for excessive padding
- Coupled with automatic tools for beam-forming & focal steering based on analytical solutions, ray tracing, & time-reversal techniques
- Built-in calculation of acoustically relevant quantities (intensity, radiation force, particle velocity, etc.)
- Database of acoustic properties
Optimized transcranial phase aberration correction for a large array FUS neurosurgery system.
Evaluation of fetal exposure to acoustic stimuli.
HIFU treatment planning for neck cancers.
