The CEM43 tissue model is used to quantify effects resulting from transient heating and is applied to define exposure thresholds . This metric, first proposed by Sapareto and Dewey , quantifies thermal exposure in terms of the number of minutes of heating at 43°C needed to obtain equivalent effects in biological tissues. The approach permits the impact of different transient heat exposure scenarios (e.g., short heating at high temperature vs. prolonged moderate heating), or a specific exposure to be compared to a previously identified damage threshold. Knowing the effect of a specific exposure duration at 43°C, the user can compare it to exposures at other temperatures and durations. CEM43 therefore provides a thermal dose concept based on temperature-weighted reaction kinetics, integrated over time, with the added benefits that it is applicable to a wide range of thermal effects from the tissue to the subcellular level, does not require tissue or reaction-specific constants, and is valid across a wide temperature range.
The biological response of a system is dependent not only on the temperature distribution but also on the sensitivity of the various tissues and the effect of interest. Tissue- and response-specific damage thresholds expressed in CEM43 have been reported in the literature  and can be used to assess potential tissue damage based on the simulated CEM43 distributions.
The Arrhenius tissue damage model is a metric that represents the percentage of tissue damaged in an affected region. For a given temperature and exposure duration, the tissue injury is calculated based on experimental cell survivability studies. Whereas CEM43 is often used to determine thresholds for a non-damaging or therapeutic exposure, the probabilistic Arrhenius model is primarily applied to determine ablated volumes in high-temperature exposure scenarios.
Treatment planning for liver radiofrequency ablation (RFA) (specific absorption rate (SAR), CEM43 thermal tissue damage assessment).
 Gerard C. van Rhoon, et. al., "CEM43°C thermal dose thresholds: a potential guide
for magnetic resonance radiofrequency exposure levels?", Eur Radiol (2013) 23:2215–2227
 Sapareto SA, Dewey WC., "Thermal dose determination in cancer therapy." Int J Radiat Oncol Biol Phys. 1984;10:787–800
 Yarmolenko PS, et. al., "Thresholds for thermal damage to normal tissues: An update." Int J Hyperthermia, 2011; 26:1–26