The Neuronal Tissue Models (T-NEURO) enable the dynamic modeling of EM-induced neuronal activation, inhibition, and synchronization using either complex, multi-compartmental representations of axons, neurons, and neuronal networks with varying channel dynamics, or generic models. Sim4Life uses the NEURON solver developed at the Yale University which is ideal for studying interaction mechanisms, evaluating and optimizing neurostimulating devices, and assessing safety issues. T-NEURO now also permits to accurately and efficiently deal with neural sensing – the simulation of measurable electric signals resulting from neural activity.
Stimulation of the vagus nerve with a multi-element cuff electrode array.
Embedded geometrical and dynamical representation of neurons (soma, axon, and dendritic tree) generate physiologically functionalized anatomical models.
The SENN model (safety standards) and more complex models can be applied inside whole-body models. The graphics user interface (GUI) facilitates the integration of other neuronal models from commonly used databases or independently derived models.
T-NEURO has been validated against published data and
ex vivo and in vivo measurements, and is continually advanced and validated.
Neuronal response modeling in MRI gradient switching fields with RF induced local temperature increases considered.
Improved DBS treatment analysis facilitated by the head model with incorporation of the Morel stereotactic atlas of the thalamus.
Propagation of the transmembrane voltage in a rat hippocampus neuron with a detailed dendritic tree.