Advanced Computational Life Science Applications at CNS*2025

We are excited to announce that we will present a packed program at the Annual Meeting of the Organization for Computational Neuroscience (CNS*2025), to be held July 5 – 9, 2025, in Florence, Italy – together with our Z43 partner IT'IS Foundation.

Kicking things off, we will host a half-day tutorial that provides participants with a hands-on introduction to our latest cloud-native platforms, o²S²PARC and Sim4Life.web:

Saturday July 5, 2025, 09:00 AM – 12:00 PM CEST, Room 5

Half-Day Tutorial “Computational Life Science in the Cloud: Neurostimulation and Bioelectronic Medicine with o²S²PARC & Sim4Life” (register here!)

09:00 AM	Intro to Image- & Cloud-Based Modeling for Real-World Applications
09:15 AM	Getting Started with o²S²PARC & Sim4Life.web
09:45 AM	Electromagnetic-Neuro Interactions Across Spatio-Temporal Scales (Brain, Spine, Peripheral Nervous System)
10:25 AM	Coffee Break
10:45 AM	Hands-On Exercises: Modeling the Brain Response to Non-Invasive Brain Stimulation Modeling Vagus nerve Stimulation for Cardiac Health
11:45 AM	Q&A and Closing Remarks

Participants will learn how Sim4Life enables image-based and regulatory-grade simulations featuring nerve and brain network models embedded within anatomically detailed representations of the human body. They will also discover how to create, execute, and automate computational pipelines in o²S²PARC to study realistic neuromodulation scenarios with a high degree of realism, ranging from network responses to non-invasive brain stimulation to the interactions between medical devices and the human body for bioelectronic medicine applications.

Attendees will directly interact with cloud-hosted pipelines that couple high-fidelity electromagnetic exposure modeling with neuronal dynamics – all in the browser, no local installations required.

Seats are limited, so register today!

Scientific Research

The IT'IS research team will also present six posters that describe their latest progress at the leading-edge of in silico neuroscience:

Poster No 039
Sunday, July 6, 2025, 17:20 CEST
In Silico Safety and Performance Assessment of Vagus Nerve Stimulation with Metamodeling-Based Uncertainty/Variability Quantification
Antonino Cassarà, Javier Garcia Ordonez, Werner Van Geit, and Esra Neufeld

Poster No 040
Sunday, July 6, 2025, 17:20 CEST
Modeling Transcranial Magnetic Stimulation: From Exposure in Personalized Head Models to Single Cell and Brain Network Dynamics Responses
Antonino Cassarà, Micol Colella, Esra Neufeld, Serena Santanche, Chiara Billi, and Micaela Liberti

Poster No 131
Monday, July 7, 2025, 16:20 CEST
Personalized Computational Models for Effective Impact-Driven Brain Stimulation
Fariba Karimi, Taylor Newton, Melanie Steiner, Antonino Cassara, Niels Kuster, and Esra Neufeld

Poster No 215
Monday, July 7, 2025, 16:20 CEST
Superior Temporal Interference Stimulation Targeting using Surrogate-based Multi-Goal Optimization
Esra Neufeld, Cedric Bujard, Melanie Steiner, and Niels Kuster (presented by Fariba Karimi)

Poster No 217
Monday, July 7, 2025, 16:20 CEST
The Generalized Activating Function: Accelerating Axonal Modeling for Optimized Neuromodulation
Javier García Ordóñez, Taylor Newton, Abdallah Alashqar, Andreas Rowald, Esra Neufeld, and Niels Kuster

Poster No 299
Tuesday, July 8, 2025, 17:00 CEST
iCSD May Produce Spurious Results in Dense Electrode Arrays
Joseph Tharayil, Esra Neufeld, Michael Reimann

For more information, see the event schedule CNS*2025 Program.

Why Meet Us in Florence?

Cloud-native workflows: Build, share and reproduce complex pipelines from magnetic resonance imaging to neuronal dynamics in minutes
Regulatory-grade in silico evidence: Validate neuromodulation devices with uncertainty-quantified EM, thermal and neuronal dynamics simulations
AI-accelerated design: Surrogate-accelerated tools slash exploration time from weeks to minutes

We look forward to exchanging ideas, forging collaborations, and enjoying some gelato together – see you in Florence! Ci vediamo a Firenze!