Sim4Life is a key component in restoring mobility after severe spinal cord injury

New paper “Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis” on Stimulation Movement Overground (STIMO) study published in Nature Medicine.

A new Nature Medicine paper reports on three patients with complete sensorimotor paralysis due to spinal cord injury who regained standing, walking, cycling, swimming, and trunk control capabilities as well as progressive recovery of full-weight-bearing capacities after biomimetic epidural electrical stimulation (EES) delivered with newly designed and validated multi-electrode paddle leads.

Patient-specific treatment modeling with Sim4Life provided by ZMT and our Z43 partner, the IT’IS Foundation, was key for identifying the safest and most effective surgical positioning of the new paddle electrode array. High-end computational modeling in Sim4Life also enabled the generation of detailed, realistic, and personalized computational models of the interactions between EES and the spinal cord neural activity array arrangements, which were used in silico to optimize the implant design and ensure proper coverage of the relevant patient population.

More information can be found here on the IT’IS website.